Vast Bioscience

The next dimension in drug discovery

Publications

Chem Biol Drug Des (2016) 87 190-199 Targeting bacterial cell wall peptidoglycan synthesis by inhibition of glycosyltransferase activity (https://www.ncbi.nlm.nih.gov/pubmed/26358369)

Nat Commun (2015) 6 7719 Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity (https://www.ncbi.nlm.nih.gov/pubmed/26194781)

Org Biomol Chem (2015) 13 4070-4079 Investigations into the decomposition of aminoacyl-substituted monosaccharide scaffolds from a drug discovery library (https://www.ncbi.nlm.nih.gov/pubmed/25736157)

J Chem Inf Model (2013) 53 1084-1099 Fighting obesity with a sugar-based library: discovery of novel MCH-1R antagonists by a new computational-VAST approach for exploration of GPCR binding sites (https://www.ncbi.nlm.nih.gov/pubmed/23590178)

J Med Chem (2010) 53 5576-5586 Biological diversity from a structurally diverse library: systematically scanning conformational space using a pyranose scaffold (https://www.ncbi.nlm.nih.gov/pubmed/20684600)

J Org Chem (2010) 75 197-203 A versatile approach toward diversity libraries using monosaccharide scaffolds (https://www.ncbi.nlm.nih.gov/pubmed/19961235)

Mini Rev Med Chem (2006) 6 1299-1309 Carbohydrate-based scaffolds in drug discovery (https://www.ncbi.nlm.nih.gov/pubmed/17168806)

ChemMedChem (2006) 1 1164-1194 Carbohydrates as scaffolds in drug discovery (https://www.ncbi.nlm.nih.gov/pubmed/16983718)

Biochem Pharmacol (2006) 71 957-967 Targeting the forgotten transglycosylases (https://www.ncbi.nlm.nih.gov/pubmed/16298347)

Methods Enzymol (2003) 369 248-267 Solid-phase oligosaccharide chemistry and its application to library synthesis (https://www.ncbi.nlm.nih.gov/pubmed/14722958)

Drug Discov Today (2003) 8 701-709 Molecular diversity through sugar scaffolds (https://www.ncbi.nlm.nih.gov/pubmed/12927513)